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Data on Safety of Intravaginal Boric Acid Use in Pregnant and Nonpregnant Women: A Narrative Review.Sexually Transmitted Diseases Dec 2021Intravaginal boric acid (IBA) represents one of the only options available to treat azole-resistant vulvovaginal candidiasis (VVC) and is included as part of multiple... (Review)
Review
Intravaginal boric acid (IBA) represents one of the only options available to treat azole-resistant vulvovaginal candidiasis (VVC) and is included as part of multiple national guidelines (including the United Kingdom and the United States) for the treatment of VVC or recurrent bacterial vaginosis. Novel products using IBA are under development for treatment and suppression of VVC and bacterial vaginosis. Use of over-the-counter or clinician-prescribed IBA in reproductive-aged women is already widespread and may increase further if drug resistance in VVC rises. However, IBA is not a Food and Drug Administration-approved drug, and safety data are sparse. Given these factors, it is important to understand the currently available data on the safety of IBA use. Herein, we set out to synthesize human and animal data (converting, where appropriate, dose and serum values to standard units to facilitate comparison) to answer 2 key questions: (1) What are the data on the safety of IBA use for women? and (2) What are the data on the safety of IBA use in pregnancy? We find that, despite gaps, available data suggest IBA use is safe, at least when used in doses commonly described in the literature as being prescribed by clinicians. Information on harms in pregnancy is limited, and data remain insufficient to change current guidelines, which recommend IBA avoidance in pregnancy.
Topics: Administration, Intravaginal; Adult; Boric Acids; Candidiasis, Vulvovaginal; Female; Humans; Pregnancy; Vaginosis, Bacterial
PubMed: 34561373
DOI: 10.1097/OLQ.0000000000001562 -
Neural Regeneration Research Oct 2016The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into...
The aim of this study was to investigate the effects of boric acid in experimental acute sciatic nerve injury. Twenty-eight adult male rats were randomly divided into four equal groups ( = 7): control (C), boric acid (BA), sciatic nerve injury (I), and sciatic nerve injury + boric acid treatment (BAI). Sciatic nerve injury was generated using a Yasargil aneurysm clip in the groups I and BAI. Boric acid was given four times at 100 mg/kg to rats in the groups BA and BAI after injury (by gavage at 0, 24, 48 and 72 hours) but no injury was made in the group BA. electrophysiological tests were performed at the end of the day 4 and sciatic nerve tissue samples were taken for histopathological examination. The amplitude of compound action potential, the nerve conduction velocity and the number of axons were significantly lower and the myelin structure was found to be broken in group I compared with those in groups C and BA. However, the amplitude of the compound action potential, the nerve conduction velocity and the number of axons were significantly greater in group BAI than in group I. Moreover, myelin injury was significantly milder and the intensity of nuclear factor kappa B immunostaining was significantly weaker in group BAI than in group I. The results of this study show that administration of boric acid at 100 mg/kg after sciatic nerve injury in rats markedly reduces myelin and axonal injury and improves the electrophysiological function of injured sciatic nerve possibly through alleviating oxidative stress reactions.
PubMed: 27904499
DOI: 10.4103/1673-5374.193247 -
Physiological Reports Mar 2023Marine teleosts ingest large amounts of seawater containing various ions, including 0.4 mM boric acid, which can accumulate at toxic levels in the body. However, the...
Marine teleosts ingest large amounts of seawater containing various ions, including 0.4 mM boric acid, which can accumulate at toxic levels in the body. However, the molecular mechanisms by which marine teleosts absorb and excrete boric acid are not well understood. Aquaporins (Aqps) are homologous to the nodulin-like intrinsic protein (NIP) family of plant boric acid channels. To investigate the potential roles of Aqps on boric acid transport across the plasma membrane in marine teleosts, we analyzed the function of Aqps of Japanese pufferfish (Takifugu rubripes) expressed in Xenopus laevis oocytes. Takifugu genome database contains 16 genes encoding the aquaporin family members (aqp0a, aqp0b, aqp1aa, aqp1ab, aqp3a, aqp4a, aqp7, aqp8bb, aqp9a, aqp9b, aqp10aa, aqp10bb, aqp11a, aqp11b, aqp12, and aqp14). When T. rubripes Aqps (TrAqps) were expressed in X. laevis oocytes, a swelling assay showed that boric acid permeability was significantly increased in oocytes expressing TrAqp3a, 7, 8bb, 9a, and 9b. The influx of boric acid into these oocytes was also confirmed by elemental quantification. Electrophysiological analysis using a pH microelectrode showed that these TrAqps increase B(OH) permeability. These results indicate that TrAqp3a, 7, 8bb, 9a, and 9b act as boric acid transport systems, likely as channels, in marine teleosts.
Topics: Animals; Xenopus laevis; Aquaporins; Oocytes; Boric Acids
PubMed: 36967473
DOI: 10.14814/phy2.15655 -
RSC Advances Sep 2021We report that boric acid, BOH, is a good precatalyst for the BH-catalyzed hydroboration of esters using pinacolborane as a borylation agent. Using microwave irradiation...
We report that boric acid, BOH, is a good precatalyst for the BH-catalyzed hydroboration of esters using pinacolborane as a borylation agent. Using microwave irradiation as an energy source, we demonstrated that a dozen esters were converted into the corresponding boronate ethers in good yields. It was also possible to use boric acid as a precatalyst to reduce carbonates and alkynes. Considering the hazardous and pyrophoric nature of BH solutions, boric acid proves to be a safe and green precatalyst for the metal-free reduction of unsaturated species.
PubMed: 35495511
DOI: 10.1039/d1ra05945a -
Materials (Basel, Switzerland) Mar 2023Friction, wear, and lubrication are inherent to all metal-forming processes. Unfortunately, they are particularly troublesome when forming titanium materials, which tend...
Friction, wear, and lubrication are inherent to all metal-forming processes. Unfortunately, they are particularly troublesome when forming titanium materials, which tend to form titanium buildup on the working surfaces of the forming tools. Lubrication is one of the most effective ways to separate contacting surfaces and eliminate galling, thus reducing tool wear. The paper presents the tribological aspects of titanium sheets forming using environmentally friendly lubricants with the addition of boric acid. The lubricant's effectiveness was assessed on the basis of technological tests, such as the strip drawing test, the Erichsen cupping test, and the formation of spherical drawn parts in industrial conditions. Moreover, the results of the numerical simulation of forming a titanium hat-shaped part are presented. Numerical calculations of forming processes were performed using the PamStamp 2G system based on the finite element method. Both experiments and numerical analyses showed the positive effect of lubricants with boric acid on sheet titanium forming.
PubMed: 36984103
DOI: 10.3390/ma16062224 -
Designed Monomers and Polymers Oct 2020The work presented here focusses on developing adhesive by blending tannin and polyvinyl alcohol (PVA) in water. To furthermore enhance the properties crosslinking is...
The work presented here focusses on developing adhesive by blending tannin and polyvinyl alcohol (PVA) in water. To furthermore enhance the properties crosslinking is carried by using boric acid at varying concentrations. Presence of free hydroxyl groups in PVA and tannin acts as a site for crosslinking reaction. The empty p orbital of trivalent boron atom attracts nucleophilic hydroxyl groups of PVA and tannin, hence are expected to form crosslinks. The interaction of boric acid with the blend was confirmed by FTIR spectra studies. The acidic pH favoured the reaction and its effects were observed by increase in viscosity and glass transition temperature (Tg). Films cased with the crosslinked blend demonstrated less hydrophilic behaviour from water contact angle test also increment in pencil hardness value and stress-bearing capacity. Adhesive performance properties like wet tack and time-dependent tensile lap shear strength on softwood and hardwood specimens were evaluated. The crosslinking-enhanced cohesion by reducing the free volumes between the chains and due to this, enhancement in tensile strength on bonded wood substrates was observed. Overall, it was found that the adhesive prepared by crosslinking PVA/tannin blend with boric acid is suitable for wood adhesive application.
PubMed: 33132742
DOI: 10.1080/15685551.2020.1826124 -
Journal of Solution Chemistry 2017An experiment based on electrochemical reactions and pH monitoring was performed in which nickel ions were gradually formed by oxidation of a nickel metal electrode in a... (Review)
Review
An experiment based on electrochemical reactions and pH monitoring was performed in which nickel ions were gradually formed by oxidation of a nickel metal electrode in a solution of boric acid. Based on the experimental results and aqueous speciation modeling, the evolution of pH showed the existence of significant nickel-boron complexation. A triborate nickel complex was postulated at high boric acid concentrations when polyborates are present, and the equilibrium constants were determined at 25, 50 and 70 °C. The calculated enthalpy and entropy at 25 °C for the formation of the complex from boric acid and Ni ions are respectively equal to (65.6 ± 3.1) kJ·mol and (0.5 ± 11.1) J·K·mol. The results of this study suggest that complexation of nickel ions by borates can significantly enhance the solubility of nickel metal and nickel oxide depending on the concentration of boric acid and pH. First principles calculations were investigated and tend to show that the complex is thermodynamically stable and the nickel cation in solution should interact more strongly with the [Formula: see text] than with boric acid.
PubMed: 28163341
DOI: 10.1007/s10953-016-0555-x -
Molecules (Basel, Switzerland) Feb 2022Phytoplasmas are economically important plant pathogenic bacterial diseases, causing severe yield losses worldwide. In this study, we tested nanoformulations such as...
Phytoplasmas are economically important plant pathogenic bacterial diseases, causing severe yield losses worldwide. In this study, we tested nanoformulations such as glycyrrhizic acid ammonium salt (GAS), salicylic acid (SA), and boric acid (BA) as novel antimicrobial agents inducing the resistance against the phytoplasma disease in faba bean. The nanoparticles (NP) were foliar-applied to naturally phytoplasma-infected faba bean with three concentrations from each of SA, GAS, and BA, under field conditions. Nested PCR (using universal primer pairs P1/P7 and R16F2n/R16R2) were reacted positively with all symptomatic samples and gave a product size of approximately 1200 bp, while the healthy plant gave no results. Transmission electron microscopy examinations of phytoplasma-infected faba bean plants treated with different nanoparticles revealed that severe damage occurred in phytoplasma particle's structure, degradation, malformation, lysis in the cell membrane, and the cytoplasmic leakage followed by complete lysis of phytoplasma cells. Exogenous application of GAS-NP (1.68 µM), SA-NP (0.28 µM), and BA-NP (0.124 µM) suppressed the infection percentage of phytoplasma by 75%, 50%, and 20%, and the disease severity by 84%, 64%, and 54%, respectively. Foliar application of nanoparticles improved Fv/Fm (maximum quantum efficiency of PSII Photochemistry), PI (the performance index), SPAD chlorophyll (the relative chlorophyll content), shoots height, and leaves number, thus inducing recovery of the plant biomass and green pods yield. The most effective treatment was GAS-NP at 1.68 µM that mediated substantial increases in the shoots' fresh weight, shoots' dry weight, number of pods per plant, and green pods yield by 230%, 244%, 202% and 178%, respectively, compared to those of infected plants not sprayed with nanoparticles. This study demonstrated the utility of using nanoparticles, particularly GAS-NP at 1.68 µM to suppress the phytoplasma infection.
Topics: Phytoplasma
PubMed: 35268567
DOI: 10.3390/molecules27051467 -
RSC Advances Sep 2021[This retracts the article DOI: 10.1039/D1RA03769B.].
[This retracts the article DOI: 10.1039/D1RA03769B.].
PubMed: 35482000
DOI: 10.1039/d1ra90141a -
PloS One 2014Saprolegnia infections cause severe economic losses among freshwater fish and their eggs. The banning of malachite green increased the demand for finding effective...
Saprolegnia infections cause severe economic losses among freshwater fish and their eggs. The banning of malachite green increased the demand for finding effective alternative treatments to control the disease. In the present study, we investigated the ability of boric acid to control saprolegniosis in salmon eggs and yolk sac fry. Under in vitro conditions, boric acid was able to decrease Saprolegnia spore activity and mycelial growth in all tested concentrations above 0.2 g/L, while complete inhibition of germination and growth was observed at a concentration of 0.8 g/L. In in vivo experiments using Atlantic salmon eyed eggs, saprolegniosis was controlled by boric acid at concentrations ranging from 0.2-1.4 g/L during continuous exposure, and at 1.0-4.0 g/L during intermittent exposure. The same effect was observed on salmon yolk sac fry exposed continuously to 0.5 g/L boric acid during the natural outbreak of saprolegniosis. During the experiments no negative impact with regard to hatchability and viability was observed in either eggs or fry, which indicate safety of use at all tested concentrations. The high hatchability and survival rates recorded following the in vivo testing suggest that boric acid is a candidate for prophylaxis and control of saprolegniosis.
Topics: Animals; Boric Acids; Fish Diseases; Fresh Water; In Vitro Techniques; Infections; Insecticides; Saprolegnia; Spores; Yolk Sac; Zygote
PubMed: 24699283
DOI: 10.1371/journal.pone.0091878